Hofmann’s Focus on ergot led him down a route of isolating and synthesizing its compounds. The focus was on making a respiratory and circulatory stimulant. It is thought that LSD as well as other psychedelics may interact with the DMN in developing the effects that arise whilst to the compound. https://medium.com/@LsdWorld/the-future-of-lsd-research-and-potential-medical-uses-40ebd16dd150