Environmental or self-antigens and homotypic interactions result in BCR and Toll-like receptor (TLR) signaling, amplifying the response of CLL cells to other indicators within the microenvironment and raising the activation of anti-apoptotic and proliferation pathways.31,32 Genomic studies have recognized recurrent mutations in genes regulating tumor mobile-microenvironment interactio... https://letitiam419els5.tusblogos.com/profile