And lastly, clonidine improves neuraxial opioids and, in combination with fentanyl, interacts within an additive way, which can reduce the dose of each element by 60% for postoperative analgesia. Clonidine treats superior hypertension by stimulating α2 receptors from the brainstem, which decreases peripheral vascular resistance, reducing blood pressure level. https://bookmarks4seo.com/story19727993/onolidine-an-overview